Faculty

Rachel Vreeman, MD, MS

Rachel Vreeman, MD, MS

Assistant Professor

Contact

(317) 278-0552 (phone)
(317) 278-0456 (fax)
rvreeman@iu.edu

Indiana Children's Health Service Research
Health Information and Translational Sciences Building
410 W. 10th Street, HS Suite 1000
Indianapolis, IN 46202-5140

Bio

Specialty

Pediatrics, Health Services Research, Global Health

Areas of Interest

Pediatric global health, pediatric HIV, resource-limited settings, adherence to antiretroviral therapy, disclosure of HIV status, dosing antiretroviral therapy for children

Dr. Rachel Vreeman is an assistant professor of pediatrics in the Children’s Health Services Research Program at the Indiana University School of Medicine and a pediatrician at Riley Hospital for Children. In addition, she is co-director of pediatric research for the Academic Model Providing Access to Healthcare, an academic collaboration between Indiana University School of Medicine and the Moi University School of Medicine in Kenya, that provides comprehensive HIV treatment for over 130,000 patients in Kenya. Dr. Vreeman is also an affiliated scientist at the Regenstrief Institute and a faculty investigator with the Center for Health Policy and Professionalism Research. Dr. Vreeman’s research work focuses on the development of instruments to improve children’s health care within resource-limited settings.

She received her MD from Michigan State University College of Human Medicine, and completed her internship, residency, and a chief residency in pediatrics at the Indiana University School of Medicine. She also completed a fellowship in Children’s Health Services Research and a master's degree in clinical research at the Indiana University School of Medicine.


Education

1998 B.A., English, Cornell University
2002 M.D., Michigan State University
2008 M.S., Clinical Research, Indiana University


Honors & Awards

1994 National Merit Scholar, Cornell University
1994-1998 Dean’s List, Cornell University
1996-1998 Cornell Tradition Fellow, Cornell University
1998 Class of 1916 Award for Most Outstanding Honors Thesis, Cornell University
2001 Monika and Manoj Mohan Scholarship, Michigan State College of Human Medicine
2001 William B. Weil, Jr. MD Endowed Scholarship, Michigan State College of Human Medicine,
2001 Alpha Omega Alpha Honor Medical Society, Michigan State University College of Human Medicine
2004 Ambulatory Pediatrics Association, Region V Resident Research Award
2004 Indiana University Pediatrics Research Day Award Recipient
2005 Dyson Initiative-Indiana University Child Advocacy Award
2006 Indiana University Pediatrics Research Day Award
2006-2008 Morris Green Pediatric Academic Scholar, Fellowship Award, Indiana University School of Medicine
2007-2009 NIH Loan Repayment Program Award for Pediatric Scientists
2008 AAMC Early Career Women Faculty Professional Development
2009 Indiana CTSI Career Development Award (KL2)
2009-2010 Indiana CTSI Career Development Award (KL2)

Clinical

Provider Clinics

AMPATH HIV Clinics, Western Kenya

Contact

(317) 278-0552 (phone)
(317) 278-0456 (fax)
rvreeman@iu.edu

Indiana Children's Health Service Research
Health Information and Translational Sciences Building
410 W. 10th Street, HS Suite 1000
Indianapolis, IN 46202-5140


Research & Grants

Research

Dr. Vreeman's research program focuses on chronic disease management for HIV-infected children in resource-limited settings, with a focus on adherence to antiretroviral therapy (ART). She is currently embarked on a series of projects to identify the most valid and useful strategy to measure pediatric ART adherence in sub-Saharan Africa. Reliable instruments are urgently needed to measure pediatric ART adherence in the resource-limited settings where most of the world’s HIV-infected children live. Dr. Vreeman is validating numerous culturally adapted, self-report items that measure ART adherence against a standard of plasma drug levels, electronic dose monitoring, pill counts and liquid volume measures. The rationale for developing validated adherence measures is to gain the ability to measure adherence accurately, which then allows us to test interventions to improve adherence and assess whether our therapies optimize clinical outcomes. Dr. Vreeman is also conducting research on how to optimize the disclosure of HIV status to HIV-infected children, whether clinical decision support strategies improve pediatric healthcare in resource-limited settings, and how the dosing of antiretroviral medicines should be altered for malnourished children.

Grants

Mentored Patient-Oriented Research Career Development Award
K23
NIH/NIMH
“Development of an Antiretroviral Therapy Adherence Measure for Pediatrics”
Will provide primary funding for career development and course of research in the design, development, and evaluation of instruments to measure pediatric adherence to antiretroviral therapy in a resource-limited setting.
Role: Principal Investigator
President’s Emergency Funds for AIDS Relief (PEPFAR) Public Health Evaluation.
#KE.09.0236
“Evaluation of a Comprehensive Strategy to Measure Pediatric Adherence to Antiretroviral Therapy.”
Will provide funding to compare the reliability and validity of strategies to measure pediatric antiretroviral therapy adherence in home-based compared to clinic-based settings.
Role: Co-Principal Investigator
1R01HD060478-01A1
NICHD
“Orphaned and Separated Children’s Assessment Related to their Health and Well-Being.”
This is an R01 award conducting yearly, standardized assessments of the care environment and the physical and mental health of orphaned children in Kenya over a period of five years.
Role: Co-investigator

Representative PublicationsView All Publications

Vreeman RC, Madsen KA, Vreeman DJ, Carroll AE, Downs SM.
“Compliance with guidelines for ADHD: A pilot study of an evaluation tool.”
Journal of Pediatrics 2006 Oct; 149(4):568-571.
Vreeman RC, Carroll AE.
“Do School-Based Interventions Prevent Bullying? A Systematic Review.”
Archives of Pediatric and Adolescent Medicine. 2007;161:78-88
Carroll AE, Vreeman RC, Buddenbaum J, Inui TS.
“To what extent do educational interventions impact medical trainees’ attitudes and behaviors regarding industry-trainee and industry-physician relationships?”
Pediatrics. 2007 120: e1528-e1535.
Vreeman RC, Carroll AE.
“Medical Myths.”
BMJ. 2007 Dec 22;335(7633):1288-9
Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM.
“A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries.”
Pediatric Infectious Diseases Journal. 2008 Aug;27(8):686-691.
Vreeman RC, Finnell SME, Cernkovich ER, Carroll AE.
“The effects of antiemetics for children with vomiting due to acute, moderate gastroenteritis.”
Archives of Pediatric and Adolescent Medicine. 2008 Sep;162(9):866-869.

Vreeman RC, Wiehe SE, Ayaya SO, Musick BS, Nyandiko WM.
“Association of antiretroviral and clinic adherence with orphan status among HIV-infected children in western Kenya.”
Journal of Acquired Immune Deficiency Syndromes. 2008 Oct 1;49(2):163-70.

Vreeman RC, Carroll AE.
“Festive medical myths.”
BMJ. 2008 Dec 17;337:a2769
Vreeman RC, Nyandiko WM, Meslin EM.
Pediatric assent for a study of antiretroviral therapy dosing for children in western Kenya: A case study in international research collaboration.
Journal of Empirical Research on Human Research Ethics. 2009 March:3(3-16)
Vreeman RC, Nyandiko WM, Sang E, Musick BS, Braitstein P, Wiehe SE.
Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya.
Conflict and Health. 2009 Apr 4:3(1):5
Braitstein P, Nyandiko WM, Vreeman RC, Wools-Kaloustian KK, Sang E, Musick BS, Sidle JE, Yiannoutsos C, Ayaya SO, Carter EJ.
The clinical burden of tuberculosis among HIV-infected children in western Kenya and the impact of combination antiretroviral treatment.
Pediatric Infectious Diseases Journal. 2009 Jul;28(7):626-632