Facilities and Resources
Children’s Health Services Research (CHSR)
The Children’s Health Services Research arm of Pediatrics is located in the Health Information and Translational Sciences Building. CHSR faculty at Indiana University School of Medicine (IUSM) represents an unusually rich concentration of pediatric informatics expertise. CHSR at IUSM is home to the CHICA system, a computer based clinical decision support system for a growing number of clinical sites that are part of the Pediatric Research Network. CHICA supports the implementation of clinical guidelines within the practice setting. CHICA recently added programs to promote asthma detection and management, smoking cessation counseling for parents of young children, and detection and treatment of attention deficit hyperactivity disorder. Moreover, CHICA can randomize by patient, by physician, or by clinic which guidelines are implemented, thus supporting randomized clinical trials in practice settings. Finally, CHICA collects data from the electronic medical record, from physicians, and from patients themselves so that several outcomes can be measured automatically. The CHICA system represents a rich environment in which young faculty can design and execute clinical translational studies in real-world clinical environments.
PResNet is the Pediatric practice-based Research Network run by CHSR. This research network incorporates over 30 community health centers, private pediatric practices and community based organizations across Indianapolis. Established in 2006, PResNet was created to facilitate pediatric-specific primary care research efforts. Since 2006 PResNet has approached a total of 5,379 potential subjects. Of these, 77% were recruited, 12% refused participation, and 11% failed to meet study criteria. PResNet gives clinical investigators access to pediatric populations throughout the city by providing recruitment strategies that are, first, compliant with federal recruitment regulations and HIPAA, and second, compatible with the workflow of a high volume practice. PResNet is both a resource to investigators and a model of compliant, non-intrusive recruitment strategies.
Regenstrief Institute (RI)
CHSR works in close collaboration with the Regenstrief Institute, an internationally-recognized informatics and healthcare research organization, which is part of the Indiana University School of Medicine. Regenstrief’s ability to search large databases to identify patient populations for research is an unparalleled research tool. RI receives $2.8 million per year in core support from the Regenstrief Foundation and has an annual budget of approximately $19.5 million generated by Institute investigators, largely derived from federal grants and contracts. RI scientists have developed the Regenstrief Medical Record System (RMRS), one of the nation's first electronic medical record systems and the keystone of many Institute activities. In addition to being a critical research tool, RMRS serves as the day-to-day electronic medical record system at Wishard Hospital, the county hospital in Indianapolis, and its affiliated community clinics. RMRS also manages data from the Riley Hospital for Children at IU Health and serves as a back-end data repository to the CHICA system. Regenstrief's informaticians have created the nation's only statewide electronic medical records system and health information exchange, which captures data from hospitals, emergency rooms, pharmacies, and laboratories across Indiana. Regenstrief is also home to the new CDC funded Indiana Center of Excellence in Public Health informatics. This Center coordinates informatics research and development to link statewide health information exchange to public health entities and to clinicians at the point of care.
The Clinical and Translational Science Institute (CTSI)
The Clinical and Translational Science Institute (CTSI) at Indiana and Purdue Universities, funded by a 5 year $25 million NIH grant, was created in May 2008 with strong support/involvement from Pediatrics. The goal of the Indiana CTSI Translational Cycle is to facilitate the conduct of clinical and translational science research: to begin at the bench, progress through to the bedside via clinical trials, expand to the community, then return to the bench for further research. The program has created research acceleration programs and supports pilot projects. Community engagement is a focus. Special assets of the Indiana CTSI include: the Regenstrief Institute and its work in medical informatics, health services research, and practice-based research networks; willing collaboration of IU Health and Wishard Hospital Health Systems; statewide life sciences movement, BioCrossroads, and related programs; diverse population linked by electronic medical record and office-based research networks. Excellent statistical resources are available thru the CTSI. The Project Development Team, based on a pediatric model, facilitates construction and performance of pilot studies. The Indiana Clinical Research Center provides clinical resources needed to conduct cutting-edge research include clinical outpatient and inpatient facilities, research nurses, lab facilities, DEXA, etc.
The Center for Health Geographics
The Center for Health Geographics represents another research resource for faculty. Representing a collaboration between CHSR, RI, the Department of Geography, and the Polis Center (a multidisciplinary academic research center concentrating on community development, religion, government, social services, information management, arts and culture), the Center for Health Geographics supports research innovation through integration of geographic information science, medical informatics, community informatics, and public health.