Nadia Carlesso MD PhD

Nadia Carlesso, MD, PhD

Assistant Professor Departments of Pediatrics & Medical & Molecular Genetics
James W. Riley Hospital for Children

PhD, University of Genoa, Italy & Harvard Medical School 1991-1995
MD, University of Medicine & Surgery of Torino, Italy 1982-1989
Internship & Residency, University of Torino, Italy 1987-1990
Fellowship, University of Turin, Italy 1990-1992
Fellowship, Harvard University 1992-1997

Our research aims at understanding how microenvironmental cues affect the coupling of cell cycle and differentiation in normal, inflammatory and malignant hematopoietic stem cells. Our research is focused on identifying pathways and networks, such as Notch, SKP2 and the CKIs, linking microenvironmental cues with the cell cycle and cell fate of hematopoietic stem cells (HSC) in inflammation and cancer. To address these questions, we are using genetically engineered mice lacking components of the Notch/SKP2 signaling pathway, sepsis as a model of acute inflammatory stress, and in vivo imaging to visualize cell-cell interactions in the bone marrow stem cell niche.