Faculty

Chandy C. John, MD, MS

Chandy C. John, MD, MS

Director, Section of Infectious Diseases and Global Health
Ryan White Professor of Pediatrics
Professor of Microbiology and Immunology

Phone: 317-274-8940
Email: chjohn@iu.edu
Ryan White Center for Pediatric Infectious Disease and Global Health,
1044 W. Walnut St, Rm 402-D,
Indianapolis, IN, 46202

 

SPECIALTY

Pediatric Infectious Diseases

AREAS OF INTEREST

Chandy C. John, M.D., M.S., holds the Ryan White Endowed Chair in Pediatric Infectious Disease and is director of the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University. Dr. John joined the faculty at Indiana University in 2015, after serving as director of the Division of Global Pediatrics at the University of Minnesota for 10 years. Dr. John’s research focuses on malaria pathogenesis, immunology and epidemiology. Key discoveries of his collaborative research team include: 1) the first prospective studies to establish that severe malaria is associated with long-term cognitive impairment in children, 2) identification of immunologic factors that increase risk of severe malaria and cognitive impairment after severe malaria; and 3) determination of geographic and immunologic factors that affect risk of malaria in areas of unstable malaria transmission.

He conducts research and training in Kenya in collaboration with colleagues at the Kenya Medical Research Institute and Moi University, and in Uganda in collaboration with colleagues at Makerere University. He is the author of more than 130 peer-reviewed publications and 30 book chapters. Dr. John serves on the Thrasher Research Fund Scientific Advisory Committee, and has served on or chaired numerous NIH and national and international study sections and review boards. Dr. John’s awards include the Pediatric Infectious Diseases Young Investigator Award (2004), and the Bailey K. Ashford Medal from the American Society of Tropical Medicine and Hygiene for contributions to tropical medicine research (2011).

Dr. John is an active clinician, specializing in pediatric infectious diseases, tropical medicine and travel medicine. As an educator, Dr. John was co-director of global health residency tracks in pediatrics at Case Western Reserve University and the University of Minnesota, and served as co-director of the Morris Green Physician-Scientist Training Program for pediatrics and medicine-pediatrics residents at Indiana University. Dr. John is also an author of essays, poetry and fiction.

Google Scholar

Research Grants and Publications

EDUCATION

1986 BS, University of Michigan
1988 MD, University of Michigan
1992 Internal Medicine and Pediatrics Residency, University of Michigan
1998 Pediatric Infectious Disease Fellowship, Case Western Reserve University
2001 MS, Case Western Reserve University

HONORS & AWARDS

  • Ryan White Endowed Chair in Pediatric Infectious Disease, Indiana University, 2015-present
  • Marguerite and James Dugger Endowed Professorship in Pediatrics, Univ. Minnesota, 2013-14
  • Bailey Ashford Medal, American Society of Tropical Medicine and Hygiene, 2011
  • Amplatz Scholar, University of Minnesota Department of Pediatrics, 2010
  • Emerging Physician Leadership Program, University of Minnesota, 2008-2011
  • Outstanding Faculty Educator, University of Minnesota, Department of Pediatrics, 2007
  • Outstanding Contribution to Resident Education, Rainbow Babies & Children’s Hospital, 2005
  • Best Contribution Award for Teaching Excellence, Case Western Reserve University, 2004
  • Young Investigator Award, Pediatric Infectious Disease Society, 2004
  • Glennan Teaching Scholar Award, Case Western Reserve University, 2002
  • AMSA International Health Fellowship, Ilorin, Nigeria, 1989
  • Bronze Beeper Award, Galens Medical Society, University of Michigan, 1989
  • Class Speaker, University of Michigan Medical School Graduation, 1988
  • Frank H. Robbins Award, University of Michigan Inteflex Program, 1988
  • Patrick J. Niland Award, University of Michigan Medical School, 1988
  • MAP-Reader's Digest International Fellowship, 1987

CLINICAL

Riley Hospital for Children, Indianapolis 


RESEARCH & GRANTS

Dr. John’s lab investigates malaria immunoepidemiology, the pathogenesis of severe malaria, and interactions between malaria and other disease states like iron deficiency and sickle cell disease.

The John Lab is a collaborative research group that conducts research at Indiana University and in Uganda (with Makerere University) and Kenya (with the Kenya Medical Research Institute and Maseno University).

The John Lab focuses on six major research questions:
1. Which host and pathogen factors contribute to development of severe malaria?
2. How does the immune response contribute to neurodevelopmental impairment in children with severe malaria?
3. How can iron deficiency be safely treated in malaria endemic areas?
4. What contributes to the increased risk of death from malaria in children with sickle cell disease?
5. How do changing transmission conditions affect development of immunity in malaria?
6. What causes malaria to persist in low transmission settings, and how might it be eliminated?

CURRENT GRANTS

1. NIH/NINDS R01 NS055349 (PI: John, CC)
04/01/08-12/31/18
Neurodevelopmental outcomes in severe malaria
The major goal of this project is to assess whether the most common forms of severe malaria all lead to neurodevelopmental impairment, and if so, by which pathways they do this.

2. NIH/NINDS/FIC D43 NS078280 (PI: John, CC)
09/01/11-05/31/16
Research training in infection and neurodevelopment in Uganda
The major goal of this project is to train Ugandan Masters and doctoral students and post-doctoral fellows in the areas of infection and neurodevelopment.

3. Doris Duke Foundation ICRA 2013139 (PI: John, CC)
9/1/13 – 8/31/16
Novel Use of Hydroxyurea in an African Region with Malaria
The major goal of this project is to determine the incidence of malaria in children with sickle cell anemia treated with hydroxyurea vs. placebo.

4. Doris Duke Foundation DDCF 2015053 (PI: John, CC)
6/1/15-11/30/16
Clinical Research Mentorship: Iron deficiency in sickle cell anemia.
The major goal of this project is to provide training for a medical student in sickle cell disease and iron deficiency.

5. Research Council of Norway ES529474 (PI: Phiri, K)
9/1/14-9/1/19
Malaria Chemoprevention for the post-discharge management of severe anemia in children in Malawi, Uganda and Kenya: Moving towards policy
Role: Co-investigator
The major goal of this project is to determine if malaria chemoprovention for a 3-month period decreases rates of readmission and death in children with severe anemia.

6. NIH/NICHD 1R01HD086124 (PIs: John, CC; Bangirana, P)
1/1/16-12/31/20
Prophylaxis against malaria to enhance child development
Role: Principal Investigator
The major goal of this project is to determine the effect of malaria prevention in pregnant women and their children on child neurodevelopment, and to identify the major mechanisms through which this malaria prevention affects child neurodevelopment.


REPRESENTATIVE PUBLICATIONS

(Full List)


1. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC. Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013. Emerg Infect Dis. 2015 Jul;21(7):1237-9. doi.org: 10.3201/eid2107.150213. PMCID pending.

2. Adebo SM, Eckerle JK, Andrews ME, Howard CR, John CC. Asymptomatic malaria and other infections in children adopted from Ethiopia, United States, 2006–2011. Emerg Infect Dis. 2015 Jul. doi.org/10.3201/eid2107.141933. PMCID PMC4480390.

3. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, John CC. Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children. Learning and Individual Differences 2015. http://dx.doi.org/10.1016/j.lindif.2015.01.010. PMCID pending.

4. Hanisch BR, Bangirana P, Opoka RO, Park GS, John CC. Thrombocytopenia May Mediate Disease Severity in Plasmodium Falciparum Malaria Through Reduced Transforming Growth Factor Beta-1 Regulation of Pro- and Anti-Inflammatory Cytokines. Pediatr Infect Dis J. 2015 Apr 16. PMCID PMC4466060.

5. Ton TG, Gladding SP, Zunt JR, John C, Nerurkar VR, Moyer CA, Hobbs N, McCoy M, Kolars JC. The development and implementation of a competency-based curriculum for training in global health research. Am J Trop Med Hyg. 2015 Jan 7;92(1):163-71. PMCID pending.

6. Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC. Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness. Crit Care. 2015 Feb 23;19:47. doi: 10.1186/s13054-015-0773-4. PMCID: PMC4339236

7. Noland GS, Jansen P, Vulule JM, Park GS, Ondigo BN, Kazura JW, Moormann AM, John CC. Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens. Acta Trop. 2015 Feb;142:47-56. doi: 10.1016/j.actatropica.2014.10.011. PMCID: PMC4277715.

8. Frosch AE, John CC. Expanding the Toolbox in Pursuit of a Strain Transcendent Malaria Vaccine. Am J Trop Med Hyg. 2015 Jan;92(1):1-2. doi: 10.4269/ajtmh.14-0662. PMCID: PMC4347362.

9. Shabani E, Opoka RO, Idro R, Schmidt R, Park GS, Bangirana P, Vercellotti GM, Hodges JS, Widness JA, John CC. High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria. Clin Infect Dis. 2015 Jan 1;60(1):27-35. PMCID: PMC4296127

10. Cusick SE, Opoka RO, Lund TC, John CC, Polgreen LE. Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. PLoS One. 2014 Dec 3;9(12):e113185. PMCID: PMC4254466

11. Frosch AE, Ondigo BN, Ayodo GA, Vulule JM, John CC, Cusick SE. Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. Am J Clin Nutr. 2014 Sep;100(3):968-73. PMCID PMC4135504

12. Ochola LA, Ayieko C, Kisia L, Magak NG, Shabani E, Ouma C, John CC. Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of Kenya after prolonged absence of malaria exposure. Infect Immun. 2014 Sep;82(9):3775-82. PMCID: PMC4187839

13. Mutanda AL, Cheruiyot P, Hodges JS, Ayodo G, Odero W, John CC. Sensitivity of fever for diagnosis of clinical malaria in a Kenyan area of unstable, low malaria transmission. Malar J. 2014 Apr 30;13(1):163. PMCID: PMC4021053.

14. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, Romero RA, Shapiro E, John CC. Severe malarial anemia is associated with long-term neurocognitive impairment. Clin Infect Dis 2014 Aug;59(3):336-44. PMCID: PMC4155441.

15. Ondigo BN, Hodges JS, Ireland KF, Magak NG, Lanar DE, Dutta S, Narum DL, Park GS, Ofulla AV, John CC. Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens. J Infect Dis. 2014 Oct 1;210(7):1123-32. PMCID: PMC4168304.

16. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC. Performance of Point-of-Care Diagnostics for Glucose, Lactate, and Hemoglobin in the Management of Severe Malaria in a Resource-Constrained Hospital in Uganda. Am J Trop Med Hyg. Am J Trop Med Hyg. 2014 Apr;90(4):605-8. PMCID: PMC3973500.

17. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC. Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children. Malar J. 2014 Feb 1;13:43. PMCID: PMC3922073.

18. Raabe VN, Sautter C, Chesney M, Eckerle JK, Howard CR, John CC. Hepatitis A Screening for Internationally Adopted Children From Hepatitis A Endemic Countries. Clin Pediatr (Phila). 2013 Oct 17. PMID: 24137028.

19. John CC. Complex Interactions of HIV Infection, Malaria, and Iron Deficiency. Clin Infect Dis. 2013 Dec; 57(11):1635-7. PMID: 23956166. PMCID: pending.

20. Ochola LA, Ng'wena GM, Noland GS, Ondigo BN, Ayodo G, John CC. The Plasmodium falciparum Antigen MB2 Induces Interferon-? and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya. J Glob Infect Dis. 2013 Oct;5(4):131-7. PMCID: PMC3958981