Dibyadyuti Datta, MS, PhD
Assistant Research Professor
Parasitology. Malaria immunology, biochemistry, and molecular biology.
AREAS OF INTEREST
Dr. Datta’s research interests and experience have been geared towards a better understanding of parasites biology at a molecular and biochemical level, with a specific focus on developing tools to fight the infection within communities. As a research technician in Dr. Nirbhay Kumar’s malaria vaccine research lab at Johns Hopkins University, she trained in specialized malaria lab techniques such as in-vitro parasite culture, mosquito rearing as well as conducting infection assays. As a PhD student in parasitology, her dissertation was focused on enhancing the immunogenicity of malaria transmission blocking DNA vaccines. Her graduate school training included murine and non-human primate immunization studies.
Dr. Datta joined Dr. Chandy John’s translational research lab at IUSM Department of Pediatrics as a postdoctoral fellow and lab manager and was responsible for establishing the laboratory component at IU, which included training and supervising students and scholars in the lab. As an Assistant Research Professor working with Dr. John, her focus is on assessment of how specific immunologic and parasitic factors influence risk of developing malaria, including severe malaria.
|2008||B.Tech, D.Y. Patil University, Navi Mumbai, Mah, India|
|2009||MS, Georgetown University, Washington D.C., USA|
|2015||PhD, Tulane University, School of Public Health and Tropical Medicine, New Orleans, LA, USA|
|2016||Postdoctoral Fellowship, Indiana University School of Medicine, Department of Pediatrics|
HONORS & AWARDS
Travel Award, American Society of Tropical Medicine and Hygiene, 2012
Delta Omega Eta Award for Best Dissertation, 2015
Alumni Inductee, Delta Omega Honors Society in Public Health – Eta Chapter, 2016
RESEARCH & GRANTS
NIH/NINDS R01 NS055349 (PI: John, CC)
Neurodevelopmental outcomes in severe malaria
This study seeks to establish the areas, frequency and severity of cognitive, neurologic and behavioral function affected by the 5 major forms of severe malaria in children 6 months to 4 years of age and to identify the immunological/inflammatory, metabolic and genetic factors associated with cognitive, neurologic and behavioral impairment in children with severe malaria.
Role: Project Manager
Doris Duke Foundation DDCF 2015053 (PI: John, CC)
Iron deficiency in sickle cell anemia.
This award supports research mentorship of a medical student to study the frequency of iron deficiency in sickle cell anemia and its relationship to anemia and infection.
Role: Project Manager
Full List [hyperlink to: https://www.ncbi.nlm.nih.gov/pubmed/?term=Dibyadyuti+Datta]
1. Datta D, Bansal GP, Gerloff DL, Ellefsen B, Hannaman D, Kumar N. Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation. Vaccine. 2017 Jan 5;35(2):264-272. doi: 10.1016/j.vaccine.2016.11.072. PubMed PMID: 27912985; PubMed Central PMCID: PMC5192010.
2. Kumar R, Ray PC, Datta D, Bansal GP, Angov E, Kumar N. Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles. Vaccine. 2015 Sep 22;33(39):5064-71. doi: 10.1016/j.vaccine.2015.08.025. PubMed PMID: 26299750; PubMed Central PMCID: PMC4577455.
3. Datta D, Bansal GP, Kumar R, Ellefsen B, Hannaman D, Kumar N. Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in Mice. Clin Vaccine Immunol. 2015 Sep;22(9):1013-9. doi: 10.1128/CVI.00185-15. PubMed PMID: 26135972; PubMed Central PMCID: PMC4550670.
4. Kumar R, Ledet G, Graves R, Datta D, Robinson S, Bansal GP, Mandal T, Kumar N. Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles. Pharm Res. 2015 Dec;32(12):3827-36. doi: 10.1007/s11095-015-1743-x. PubMed PMID: 26113235; PubMed Central PMCID: PMC4628851.