Chandy John Lab

Photo-Chandy-John-Lab-2017.jpgThe John lab conducts studies in labs at Indiana University, at Makerere University in Uganda and at the Kenya Medical Research Institute in Kenya. The focus of our research is on malaria, one of the leading causes of death and long-term morbidity in children under 5 years of age worldwide. 

Dr. John’s studies focus on malaria pathogenesis, immunology and epidemiology; the relationships between infection, nutrition and neurodevelopment; and infections in children with sickle cell anemia.

Ongoing Studies

Neurodevelopmental outcomes in children with severe malaria
Novel Use of Hydroxyurea in an African Region with Malaria
Clinical Research Mentorship:  Iron Deficiency in Sickle Cell Anemia
Malaria Chemoprevention for the post-discharge management of severe anemia in children in Malawi, Uganda and Kenya: Moving towards policy
Research Training in Infection and Neurodevelopment in Uganda
Malaria Transmission and Immunity                           


Neurodevelopmental outcomes in children with severe malaria

Award Number: R01 NS055349
Funding Agency: NINDS
PI: Chandy John; Co-investigator: Andrea Conroy
Dates: 04/15/08 - 12/31/18
Sites: Kampala and Jinja, Uganda

Goal: This study seeks to establish the areas, frequency and severity of cognitive, neurologic and behavioral function affected by the 5 major forms of severe malaria in children 6 months to 4 years of age and to identify the immunological/inflammatory, metabolic and genetic factors associated with cognitive, neurologic and behavioral impairment in children with severe malaria.

 
Novel Use of Hydroxyurea in an African Region with Malaria

Photo-Chandy-John-Africa.jpg

Award Number: DDICRA 2013139
Funding Agency: Doris Duke Charitable Foundation
PI: Chandy John
Dates: 09/01/13 - 08/31/16
Site: Kampala, Uganda

Goal: This study is a randomized controlled trial assessing the effects of hydroxyurea therapy vs. placebo on incidence of malaria in Ugandan children with sickle cell disease.  


Clinical Research Mentorship:  Iron deficiency in Sickle Cell Anemia

Award Number: DDCF 2015053
Funding Agency: Doris Duke Charitable Foundation
PI: Chandy John
Dates: 06/01/15 - 11/30/16
Site: Kampala, Uganda

Goal: This award supports research mentorship of a medical student to study the frequency of iron deficiency in sickle cell anemia and its relationship to anemia and infection. 


Malaria Chemoprevention for the post-discharge management of severe anemia in children in Malawi, Uganda and Kenya: Moving towards policy

Award Number: ES529474
Funding Agency: Research Agency of Norway
PI: Kamija Phiri; Co-investigator: Chandy John
Dates: 09/01/14 - 09/01/19
Sites: Malawi, Uganda and Kenya

Goal: The major goal of this project is to determine if malaria chemoprevention for a 3-month period decreases rates of readmission and death in children with severe anemia.


Research Training in Infection and Neurodevelopment in Uganda

Award Number: D43 NS078280
PI: Chandy John
Funding Agency: NINDS/Fogarty International Center
Dates: 08/01/11 - 07/31/16
Site: Kampala, Uganda

Goal: This grant provides doctoral level training for students in neuropsychology, immunology, biostatistics, and epidemiology, Masters in Medicine training for pediatric and internal medicine residency, and training in mentorship for faculty members at Makerere University. 


Malaria Transmission and Immunity

RWC
PI: Chandy John
Funding Agency: RWC
Dates: 01/01/15 - 12/31/20
Sites: Kisumu and North Nandi County, Kenya

Goal: The goal is this study is to understand how changes in malaria transmission, and particularly a sharp decrease in malaria transmission, affects immune responses to malaria, and to assess whether a decrease in specific responses may lead to increased future susceptibility to malaria.