Faculty

Edward Liechty, MD

Edward Liechty, MD

Phone: (317) 274-4715
Email: eliecht@iupui.edu
Address:
699 Riley Hospital Drive
Indianapolis, IN 46202

Bio

Specialty

Certified, American Board of Pediatrics - Pedaitrics, Neonatal-Perinatal Medicine

Areas of Interest

  • International Child Health
  • Perinatal epidemiology
  • Nutrition
  • Clinical Research

My research focus has changed significantly in the past few years. For most of my career I have used the chronically catheterized fetal sheep model to investigate the regulation of fetal growth and amino acid/protein metabolism. However, after spending a sabbatical year in Kenya I have become increasingly interested in international health. It is apparent that the major causes of fetal, neonatal and maternal mortality in the developing world are to a large extent preventable. I am now a principal investigator in the Global Network for Women's and Children's Health Research http://gn.rti.org/index.cfm. This is an NIH funded multicenter clinical research network formed to investigate cost effective sustainable interventions to decrease maternal and infant mortality. Current studies we are conducting include 1) evaluation of a training program for lay midwives and 2) evaluation of a meat based versus cereal based protein supplement in 6-18 month old infants. We are also employing Geographical Information Systems (GIS) to evaluate spatial independent variables as well as more traditional parameters in determining health outcomes. I continue to be interested in endocrine and nutritional problems, and we are also using stable isotopes to investigate protein ad energy metabolism in Kenyan infants and children, including those with HIV/AIDS.

Education

1974 B.A., Goshen College
1978 M.D., Indiana University School of Mecine

Honors & Awards


Clinical

  • Riley Hospital for Children
  • Wishard Hospital
  • St Francis Hosptiatal

 


Research & Grants

I am now a principal investigator in the Global Network for Women's and Children's Health Research http://gn.rti.org/index.cfm. This is an NIH funded multicenter clinical research network formed to investigate cost effective sustainable interventions to decrease maternal and infant mortality. Current studies we are conducting include 1) evaluation of a training program newborn resucutaion (Helping Babies Breathe) 2) evaluation of an implementation program for increasing coverage of antenatal corticsteroids for woen in premature labor. We are also employing Geographical Information Systems (GIS) to evaluate spatial independent variables as well as more traditional parameters in determining health outcomes. I continue to be interested in endocrine and nutritional problems, and we are also using stable isotopes to investigate protein ad energy metabolism in Kenyan infants and children, including those with HIV/AIDS.

Current Grants

NIH 1U10HD076461-01 (Liechty)
05/01/20013 – 04/30/18
Global Network for Women’s and Children’s Health Research
This is a cooperative project to institute common clinical research protocols in developing countries, focused on women’s and children’s health.
Role:  PI

NCRR UL1RR025761-01 (Anantha Shekhar)
05/01/08 – 04/30/13                    
Indiana Clinical and Translational Sciences Institute
To establish a new institute that facilitates clinical and translational biomedical research across the state of Indiana.  This is an institute established by the CTSA to Indiana and Purdue Universities.
Role: Co-I


Representative PublicationsView All Publications

1. W. Shen, D. W. Boyle and E. A. Liechty Changes in 4E-BP1 and p70S6K Phosphorylation in Skeletal Muscle of the Ovine Fetus after Prolonged Maternal Fasting: Effects of Insulin and IGF-I. Pediatr Res. 2005 58: 833-839.

2. W. Shen, P. Wisniowski, S. C. Denne, D. W. Boyle and E. A. Liechty The Anabolic Effects of Insulin and IGF-I in the Ovine Fetus are Reduced by Prolonged Maternal Fasting. Am J Physiol Endocrinol Metab. 2005 288: E907-E913.

3. W. H. Shen, D. W. Boyle, P. Wisniowski, A. Bade and E. A. Liechty Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino acids. J Endocrinol. 2005 185: 275-89.

4. Joshi MA, Jeoung NH, Obayashi M, Hattab EM, Brocken EG, Liechty EA, Kubek MJ, Vattem KM, Wek RC, and Harris RA. Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.[see comment]. Biochemical Journal 400: 153-162, 2006.

5. J. Kubek, K. M. Vattem, R. C. Wek and R. A. Harris Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.[see comment]. Biochemical Journal. 2006 400: 153-62.

6. S. O. Ayaya, E. Liechty, J. H. Conway, T. Kamau and F. O. Esamai Training needs for mid-level managers and immunisation coverage in Western Kenya. East Afr Med J. 2007 84: 342-52.

7. W. H. Shen, Z. Chen, S. Shi, H. Chen, W. Zhu, A. Penner, G. Bu, W. Li, D. W. Boyle,M. Rubart, L. J. Field, R. Abraham, E. A. Liechty and W. Shou Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function. J Biol Chem. 2008 283: 13842-9.

8. Zhu W, Soonpaa MH, Chen H, Shen W, Payne RM, Liechty EA, Caldwell RL, Shou W, Field LJ: Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway. Circulation 2009, 119:99-106.

9. Liechty EA: The resistant premie: documenting the prevalence of hyperglycemia in the extremely low birth weight infant. J Pediatr 2010, 157:699-700.

10. Pasha O, Goldenberg RL, McClure EM, Saleem S, Goudar SS, Althabe F, Patel A, Esamai F, Garces A, Chomba E, et al: Communities, Birth Attendants and Health Facilities: A Continuum of Emergency Maternal and Newborn Care (The Global Network's EmONC Trial). BMC Pregnancy Childbirth 2010, 10:82.

11. Blanco CL, Gong AK, Green BK, Falck A, Schoolfield J, Liechty EA: Early Changes in Plasma Amino Acid Concentrations during Aggressive Nutritional Therapy in Extremely Low Birth Weight Infants. J Pediatr 2011, 158:543-548 e541.

12. McClure EM, Pasha O, Goudar SS, et al. Epidemiology of stillbirth in low-middle income countries: a global network study. Acta Obstet Gynecol Scand. Sep 14 2011.

13. Gisore P, Shipala E, Otieno K, Rono B, Marete I, Tenge C, et al. Community based weighing of newborns and use of mobile phones by village elders in rural settings in Kenya: a decentralised approach to health care provision. BMC Pregnancy Childbirth 2012;12(1):15.

14. Garces A, McClure EM, Chomba E, Patel A, Pasha O, Tshefu A, et al. Home birth attendants in low income countries: who are they and what do they do? BMC Pregnancy Childbirth 2012;12(1):34.

15. Blanco CL, Gong AK, Schoolfield J, Green BK, Daniels W, Liechty EA, et al. Impact of Early and High Amino Acid Supplementation on ELBW Infants at 2 Years. J Pediatr Gastroenterol Nutr 2012;54(5):601-607.

16. Althabe F, Belizan J, Mazzoni A, Berrueta M, Hemingway-Foday J, Koso-Thomas M, et al. Antenatal corticosteroids trial in preterm births to increase Neonatal survival in developing countries: Study protocol. Reprod Health. 2012;9(1):22.

17. Belizan JM, McClure EM, Goudar SS, et al. Neonatal Death in Low- to Middle-Income Countries: A Global Network Study. American journal of perinatology. May 29 2012.

18. Blanco CL, Gong AK, Schoolfield J, et al. Impact of Early and High Amino Acid Supplementation on ELBW Infants at 2 Years. Journal of pediatric gastroenterology and nutrition. May 2012;54(5):601-607.

19. Manasyan A, Saleem S, Koso-Thomas M, et al. Assessment of Obstetric and Neonatal Health Services in Developing Country Health Facilities. American journal of perinatology. Jan 17 2013.

20. Marete I, Tenge C, Pasha O, et al. Perinatal Outcomes of Multiple-Gestation Pregnancies in Kenya, Zambia, Pakistan, India, Guatemala, and Argentina: A Global Network Study. American journal of perinatology. Mar 19 2013