Faculty

Laura Haneline, MD

Laura Haneline, MD

Director, Section of Neonatal-Perinatal Medicine
Edwin L. Gresham Professor of Pediatrics

Asst.: Tammy Tucker
Asst. Phone: (317) 274-4782
Asst. Email: Tamatuck@iu.edu
Address:
699 Riley Hospital Dr, RR 208
Indianapolis, IN 46202

Bio

Specialty

Neonatology

Areas of Interest

Understanding how dysfunction of stem and progenitor cells promotes the development of hematopoietic and vascular diseases.

Dr. Haneline received her Bachelor’s Degree from Ball State University and M.D. from Indiana University School of Medicine.  She completed her Pediatric Residency and Neonatal-Perinatal Medicine Fellowship at Indiana University School of Medicine.  She is a Professor of Pediatrics and serves as the Associate Director of the Neonatal-Perinatal Medicine Division and the Medical Director for the Neonatal Nurse Practitioner Program.     Dr. Haneline is an Investigator in the Herman B Wells Center for Pediatric Research.  She has published over 40 manuscripts and book chapters.  She serves in numerous roles at scientific meetings and is a standing member of a National Institutes of Health Study Section.
 
Her main research areas include:
 
1) Examining the impact of maternal diabetes on neonatal endothelial progenitor cell function and role in development of cardiovascular disease
 
2) Evaluating whether circulating stem/progenitor cells can be used as biomarkers of disease in pregnancy or after stem cell transplantation.
 

Education

1999 Fellow, Neonatal-Perinatal Medicine, Indiana University School of Medicine
1994 Resident, Pediatrics, Indiana University School of Medicine
1991 M.D., Indiana University School of Medicine

Honors & Awards

1996 Member, Alpha Omega Alpha
1999 Basic Science Research Award, Society of Pediatric Research
1999-2006 Assistant Professor of Pediatrics, Indiana University School of Medicine
2003-2006 Assistant Professor of Microbiology/Immunology, Indiana University School of Medicine
2000-Present Member, Indiana University School of Medicine Cancer Center – NIH funded
2001 Young Investigator Award, Perinatal Research Society
2001 Young Investigator Award, American Society for Clinical Investigation
2004-Present Associate Member of Graduate School Faculty, Indiana University School of Medicine
2005, 2007 Ad Hoc reviewer, NIH - Clinical Hematology Study Section
2006-Present Associate Professor of Pediatrics and Microbiology/Immunology
2006 1st Place Translational Research Award, International Fanconi Anemia Meeting
2007 Reviewer, NIH - Shared Resource Grant
2008 Guest Editor, Antioxidants & Redox Signaling
2008 Faculty member of F1000 Medicine
2009 Associate Director of Neonatal-Perinatal Medicine, Indiana University School of Medicine
2009 Election into Perinatal Research Society
2009 Election into the American Society of Clinical Investigation
2009 NHLBI BioResource program grant reviewer
2009 Department of Defense grant reviewer - Bone Marrow Failure Research Program
2009 NHLBI P01 grant review

Clinical

  • Riley Hospital for Children at IU Health
  • IU Health University Hospital
  • Eskenazi Health

Research & Grants

Dr. Haneline is a stem cell biologist whose research focuses on how adverse intrauterine environments impair the function of fetal stem and progenitor cells thereby enhancing risk for hematopoietic and vascular diseases during childhood. She is investigating the basis for  dysfunction of fetal stem and progenitor cells after maternal diabetes exposure.  Studies from her lab previously showed that angiogenic progenitor cells are reduced in women with gestational diabetes.  These findings suggest that angiogenic progenitors may serve as a marker to identify women at high risk for pregnancy complications before symptoms. Based on these data, she is studying medication effects on circulating progenitor cells during healthy and high-risk pregnancies. This is an exciting area of research that allows collaborations with neonatologists, obstetricians, clinical pharmacologists, and basic scientists.  Ultimately, the goals of her research are: 1) improve fetal and neonatal development by elucidating  mechanisms involved in stem/progenitor cell dysfunction after adverse intrauterine environment  exposure and 2) enhance the health of women by prospective identification of gestational disease risk to prevent morbidities of women and infants.  National recognition include election into the American Society of Clinical Investigation, an honor society for physician-scientists, and the American Pediatric Society.

Current Grants

Endothelial progenitor and vascular dysfunction in infants of diabetic mothers, R01, NIH, Principal Investigator

Obstetric Pharmacology Research Unit Network, U10, NIH, Basic Science Principal Investigator

Indiana University Center for Pediatric Pharmacology, U54, NIH, Principal Investigator

Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, U10, NIH, Co-Investigator

Cellular Biomarkers of Sinusoidal Obstructive Syndrome, CTSI Core Grant, Principal Investigator

Postdoctoral Research Training in Pediatric Clinical Pharmacology, T32, NIH, Mentor

Indianapolis Predictive Obesity Center for Children, INtramural Funding, Principal Investigator


Representative PublicationsView All Publications

1. Case J, Haneline LS, Yoder MC, Ingram DA. Reply to Fadini et al: Critical assessment of putative endothelial progenitor phenotypes. Exp Hematol, 35(10):1481-1482 2007.

2. Li B, Jia N, Waning DL, Yang FC, Haneline LS, Chun KT. Cul4A is required for hematopoietic stem-cell engraftment and self-renewal. Blood. 2007 Oct 1;110(7):2704-2707. PMCID: PMC1988932

3. Ingram DA, Lien IZ, Mead LE, Estes M, Prater DN, Derr-Yellin E, DiMeglio LA, Haneline LS. In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function. Diabetes. 2008 Mar;57(3):724-731. PMC Journal- In Process

4. Javed MJ, Mead LE, Prater D, Bessler WK, Foster D, Case J, Goebel WS, Yoder MC, Haneline LS, and Ingram DA. Endothelial Colony Forming Cells and Mesenchymal Stem Cells are Enriched at Different Gestational Ages in Human Umbilical Cord Blood. Pediatr Res. 2008 Jul;64(1):68-73.

5. Haneline LS. Redox Regulation of Stem and Progenitor Cells. Antioxid Redox Signal. 2008 Nov;10(11):1849-1852. PMCID: PMC2574609

6. Case J, Ingram DA, Haneline LS. Oxidative Stress Impairs Endothelial Progenitor Cell Function. Antioxid Redox Signal. 2008 Nov;10(11):1895-1907. PMCID: PMC2575029

7. Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth. Am J Physiol Heart Circ Physiol. 2009 296(3):H877-H886. PMCID: PMC2660231

8. Saadatzadeh MR, Bijangi-Vishehsaraei K, Kapur R, Haneline LS. Distinct roles of stress-activated protein kinases in Fanconi anemia type C deficient hematopoiesis. Blood. 2009 Mar 19;113(12):2655-2660. PMCID: PMC2661855

9. Haneline LS. TERTrific hormones promote hematopoiesis. Invited commentary, Blood. 2009 Sep 10;114(11):2207-2208.

10. Rhee DB, Wang Y, Mizesko M, Zhou F, Haneline L, Liu Y. FANCC suppresses short telomere-initiated telomere sister chromatid exchange. Hum Mol Genet. 2010 Mar 1;19(5):879-887. PMCID: PMC2816614 *Corresponding author

11. DiMeglio LA, Tosh A, Saha C, Estes M, Mund J, Mead LE, Lien I, Ingram DA, Haneline LS. Endothelial abnormalities in young adults with Type 1 Diabetes: a biomarker for vascular sequelae? J Pediatr. 2010 Oct;157(4):540-546. *Commentary in J Pediatr

12. Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W. Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development. 2011 Jan;138(2):303-315.

13. Acosta JC, Haas D, Saha C, DiMeglio LA, Ingram DA, and Haneline LS. Gestational diabetes alters maternal and neonatal circulating endothelial progenitor cell subsets. Am J Obstet Gynecol. 2011 Mar; 204(3):254.e8-254.e15.

14. Park SJ, Beck BD, Saadatzadeh MR, Haneline LS, Clapp DW, Lee SH. Fanconi anemia D2 protein is an apoptotic target mediated by caspases. J Cell Biochem. 2011 Sep;112(9):2383-91.

15. Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W. Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96.

16. Liu Y, Ballman K, Li D, Khan S, Derr-Yellin E, Shou W, Haneline LS. Impaired Function of Fanconi Anemia Type C Deficient Macrophages. J of Leuk Biol. 2012 Feb;91(2):333-40.

17. Li D, Zhang W, Liu Y, Haneline LS, Shou W. Lack of Plakoglobin in epidermis leads to keratoderma. J Biol Chem. 2012 Mar 23;287(13):10435-43.

18. Costantine MM, Cleary K; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric--Fetal Pharmacology Research Units Network. Pravastatin for the prevention of preeclampsia in high-risk pregnant women. Obstet Gynecol. 2013 Feb;121(2 Pt 1):349-53.

19. Chang DV, Tiller CJ, Kisling J, Case J, Mund JA, Haneline LS, Ingram DA, Tepper RS. Membrane and Capillary Components of Lung Diffusion in Early Life: Relationship to Angiogenic Cells. Eur Respir J. 2013, in press.

20. Blue EK, DiGiuseppe R, Derr-Yellin E, Acosta JC, Mund JA, Case J, and Haneline LS. Gestational Diabetes Induces Alterations in the Function of Neonatal Endothelial Colony Forming Cells. Pediatr Res. 2013, in press.