Laura Haneline, MD
Director, Section of Neonatal-Perinatal Medicine
Edwin L. Gresham Professor of Pediatrics
Asst.: Tammy Tucker
Asst. Phone: (317) 274-4782
Asst. Email: Tamatuck@iu.edu
699 Riley Hospital Dr, RR 208
Indianapolis, IN 46202
Areas of Interest
Understanding how dysfunction of stem and progenitor cells promotes the development of hematopoietic and vascular diseases.
|1999||Fellow, Neonatal-Perinatal Medicine, Indiana University School of Medicine|
|1994||Resident, Pediatrics, Indiana University School of Medicine|
|1991||M.D., Indiana University School of Medicine|
Honors & Awards
|1996||Member, Alpha Omega Alpha|
|1999||Basic Science Research Award, Society of Pediatric Research|
|1999-2006||Assistant Professor of Pediatrics, Indiana University School of Medicine|
|2003-2006||Assistant Professor of Microbiology/Immunology, Indiana University School of Medicine|
|2000-Present||Member, Indiana University School of Medicine Cancer Center – NIH funded|
|2001||Young Investigator Award, Perinatal Research Society|
|2001||Young Investigator Award, American Society for Clinical Investigation|
|2004-Present||Associate Member of Graduate School Faculty, Indiana University School of Medicine|
|2005, 2007||Ad Hoc reviewer, NIH - Clinical Hematology Study Section|
|2006-Present||Associate Professor of Pediatrics and Microbiology/Immunology|
|2006||1st Place Translational Research Award, International Fanconi Anemia Meeting|
|2007||Reviewer, NIH - Shared Resource Grant|
|2008||Guest Editor, Antioxidants & Redox Signaling|
|2008||Faculty member of F1000 Medicine|
|2009||Associate Director of Neonatal-Perinatal Medicine, Indiana University School of Medicine|
|2009||Election into Perinatal Research Society|
|2009||Election into the American Society of Clinical Investigation|
|2009||NHLBI BioResource program grant reviewer|
|2009||Department of Defense grant reviewer - Bone Marrow Failure Research Program|
|2009||NHLBI P01 grant review|
- Riley Hospital for Children at IU Health
- IU Health University Hospital
- Eskenazi Health
Research & Grants
Dr. Haneline is a stem cell biologist whose research focuses on how adverse intrauterine environments impair the function of fetal stem and progenitor cells thereby enhancing risk for hematopoietic and vascular diseases during childhood. She is investigating the basis for dysfunction of fetal stem and progenitor cells after maternal diabetes exposure. Studies from her lab previously showed that angiogenic progenitor cells are reduced in women with gestational diabetes. These findings suggest that angiogenic progenitors may serve as a marker to identify women at high risk for pregnancy complications before symptoms. Based on these data, she is studying medication effects on circulating progenitor cells during healthy and high-risk pregnancies. This is an exciting area of research that allows collaborations with neonatologists, obstetricians, clinical pharmacologists, and basic scientists. Ultimately, the goals of her research are: 1) improve fetal and neonatal development by elucidating mechanisms involved in stem/progenitor cell dysfunction after adverse intrauterine environment exposure and 2) enhance the health of women by prospective identification of gestational disease risk to prevent morbidities of women and infants. National recognition include election into the American Society of Clinical Investigation, an honor society for physician-scientists, and the American Pediatric Society.
Endothelial progenitor and vascular dysfunction in infants of diabetic mothers, R01, NIH, Principal Investigator
Obstetric Pharmacology Research Unit Network, U10, NIH, Basic Science Principal Investigator
Indiana University Center for Pediatric Pharmacology, U54, NIH, Principal Investigator
Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, U10, NIH, Co-Investigator
Cellular Biomarkers of Sinusoidal Obstructive Syndrome, CTSI Core Grant, Principal Investigator
Postdoctoral Research Training in Pediatric Clinical Pharmacology, T32, NIH, Mentor
Indianapolis Predictive Obesity Center for Children, INtramural Funding, Principal Investigator
1. Case J, Haneline LS, Yoder MC, Ingram DA. Reply to Fadini et al: Critical assessment of putative endothelial progenitor phenotypes. Exp Hematol, 35(10):1481-1482 2007.
2. Li B, Jia N, Waning DL, Yang FC, Haneline LS, Chun KT. Cul4A is required for hematopoietic stem-cell engraftment and self-renewal. Blood. 2007 Oct 1;110(7):2704-2707. PMCID: PMC1988932
3. Ingram DA, Lien IZ, Mead LE, Estes M, Prater DN, Derr-Yellin E, DiMeglio LA, Haneline LS. In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function. Diabetes. 2008 Mar;57(3):724-731. PMC Journal- In Process
4. Javed MJ, Mead LE, Prater D, Bessler WK, Foster D, Case J, Goebel WS, Yoder MC, Haneline LS, and Ingram DA. Endothelial Colony Forming Cells and Mesenchymal Stem Cells are Enriched at Different Gestational Ages in Human Umbilical Cord Blood. Pediatr Res. 2008 Jul;64(1):68-73.
5. Haneline LS. Redox Regulation of Stem and Progenitor Cells. Antioxid Redox Signal. 2008 Nov;10(11):1849-1852. PMCID: PMC2574609
6. Case J, Ingram DA, Haneline LS. Oxidative Stress Impairs Endothelial Progenitor Cell Function. Antioxid Redox Signal. 2008 Nov;10(11):1895-1907. PMCID: PMC2575029
7. Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth. Am J Physiol Heart Circ Physiol. 2009 296(3):H877-H886. PMCID: PMC2660231
8. Saadatzadeh MR, Bijangi-Vishehsaraei K, Kapur R, Haneline LS. Distinct roles of stress-activated protein kinases in Fanconi anemia type C deficient hematopoiesis. Blood. 2009 Mar 19;113(12):2655-2660. PMCID: PMC2661855
9. Haneline LS. TERTrific hormones promote hematopoiesis. Invited commentary, Blood. 2009 Sep 10;114(11):2207-2208.
10. Rhee DB, Wang Y, Mizesko M, Zhou F, Haneline L, Liu Y. FANCC suppresses short telomere-initiated telomere sister chromatid exchange. Hum Mol Genet. 2010 Mar 1;19(5):879-887. PMCID: PMC2816614 *Corresponding author
11. DiMeglio LA, Tosh A, Saha C, Estes M, Mund J, Mead LE, Lien I, Ingram DA, Haneline LS. Endothelial abnormalities in young adults with Type 1 Diabetes: a biomarker for vascular sequelae? J Pediatr. 2010 Oct;157(4):540-546. *Commentary in J Pediatr
12. Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W. Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development. 2011 Jan;138(2):303-315.
13. Acosta JC, Haas D, Saha C, DiMeglio LA, Ingram DA, and Haneline LS. Gestational diabetes alters maternal and neonatal circulating endothelial progenitor cell subsets. Am J Obstet Gynecol. 2011 Mar; 204(3):254.e8-254.e15.
14. Park SJ, Beck BD, Saadatzadeh MR, Haneline LS, Clapp DW, Lee SH. Fanconi anemia D2 protein is an apoptotic target mediated by caspases. J Cell Biochem. 2011 Sep;112(9):2383-91.
15. Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W. Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96.
16. Liu Y, Ballman K, Li D, Khan S, Derr-Yellin E, Shou W, Haneline LS. Impaired Function of Fanconi Anemia Type C Deficient Macrophages. J of Leuk Biol. 2012 Feb;91(2):333-40.
17. Li D, Zhang W, Liu Y, Haneline LS, Shou W. Lack of Plakoglobin in epidermis leads to keratoderma. J Biol Chem. 2012 Mar 23;287(13):10435-43.
18. Costantine MM, Cleary K; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric--Fetal Pharmacology Research Units Network. Pravastatin for the prevention of preeclampsia in high-risk pregnant women. Obstet Gynecol. 2013 Feb;121(2 Pt 1):349-53.
19. Chang DV, Tiller CJ, Kisling J, Case J, Mund JA, Haneline LS, Ingram DA, Tepper RS. Membrane and Capillary Components of Lung Diffusion in Early Life: Relationship to Angiogenic Cells. Eur Respir J. 2013, in press.
20. Blue EK, DiGiuseppe R, Derr-Yellin E, Acosta JC, Mund JA, Case J, and Haneline LS. Gestational Diabetes Induces Alterations in the Function of Neonatal Endothelial Colony Forming Cells. Pediatr Res. 2013, in press.