R. Mark Payne, MD

R. Mark Payne, MD

Director, Translational Research Training Program of Indiana CTSI
Professor of Pediatrics
Associate, Department of Medical and Molecular Genetics
Associate, Department of Integrative and Cellular Physiology

Phone: (317) 274-8906
Email: rpayne@iu.edu
705 Riley Hospital Drive
Riley Research
Room 127
Indianapolis, IN 46202



Pediatric Cardiology

Areas of Interest

Heart Failure in Children, Cardiomyopathy, Therapeutic development in children

Dr. R. Mark Payne received his MD from University of Texas School of Medicine, Houston.  He completed his residency in pediatrics, his pediatric cardiology fellowship, and a research fellowship in molecular biology at the Children's Hospital at Washington University School of Medicine, St Louis.  He is certified by the American Board of Pediatrics in Cardiology, and is a Fellow of the American Academy of Pediatrics and the American College of Cardiology.  Dr. Payne is a tenured Professor of Pediatric Cardiology with a secondary appointment in the Department of Medical and Molecular Genetics.  Research in his clinic and laboratory is focused on understanding cardiomyopathies and heart failure in children, and developing new therapies to repair or prevent children's heart disease.  He sees children and young adults in his clinic who have congenital heart disease, as well as cardiomyopathies such as Friedreich's Ataxia.


1977 BS, Washington & Lee University
1983 MD, University of Texas School of Medicine
1987 Pediatrics Residency, Washington University School of Medicine
1990 Pediatric Cardiology Fellowship, Washington University School of Medicine
1992 Molecular Biology Postdoctoral Fellowship, Washington University School of Medicine

Honors & Awards

1986-1987 Chief Resident in Pediatrics, Washington University School of Medicine
1989-1990 American Heart Association (AHA) Fellowship Award
1990-1992 NIH NRSA individual fellowship award 1F32HL08332-01
1994 American Society for Biochemistry and Molecular Biology
1995 American Heart Association (Basic Science Council, and CV Diseas in Young)
1997 Fellow of the American College of Cardiology (FACC)
1992-1997 AHA Clinician Scientist Award
1998 Society of Pediatric Research
1999 AHA Established Investigator Award
2003-2006 AHA  molecular signaling study section (Chair 2005-06)
2004-2010 Member NIH BRT-A study section (basic research training) (Chair 2009-10)
2006 Fellow American Academy of Pediatrics (FAAP)
2007 Member, Friedreich's Ataxia Research Alliance scientific advisory board



Riley Children's Hospital
IU Health North 

Research & Grants

Heart Failure in children
Cardiomyopathy in children
Therapeutic development in children

Representative PublicationsView All Publications

Wagner GR and Payne RM. Widespread and enzyme-independent N?-acetylation and N?-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J Biol Chem. 2013, Oct 4;288(40):29036-45, PMID: 23946487.

Lynch DR, Pandolfo M, Schulz JB, Perlman S, Delatycki MB, Payne RM, Shaddy R, Fischbeck KH, Farmer J, Kantor P, Raman SV, Hunegs L, Odenkirchen J, Miller K, Kaufmann P. Common Data Elements for Clinical Research in Friedreich Ataxia. Mov Disord. 2013 Feb;28(2):190-5. PMID:23239403.

Wagner GR, Pride PM, Babbey CM, Payne RM. Friedreich’s Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase. Hum Mol Genet, 2012, June 15;21(12):2688-97.  PMID: 22394676.

Vyas PM, Tomamichel WJ, Pride PP, Babbey CM, Wang Q, Mercier J, Martin EM, and Payne RM.  A TAT-Frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich’s Ataxia mouse model. Hum Mol Genet, 2012 Mar 15;21(6):1230-1247. PMID: 22113996.

Payne RM, The Heart in Friedreich’s Ataxia: Basic Findings and Clinical Implications. Progress in Pediatric Cardiology 2011, May;31(2):103-109. PMID: 21691434.

Wagner GR, and Payne RM. Mitochondrial Acetylation and Diseases of Aging. J Aging Res. 2011 Mar 7; 2011:234875. PMID 21437190.

Zhang W, Chen H, Wang Y, Yong W, Zhu W, Liu Y, Wagner GR, Payne RM, Field LJ, Xin H, Cai CL, Shou W. Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function.  J Biol Chem. 2011 Oct 21;286(42):36820-9. PMID: 21890625.

Payne RM, Pride PM, Babbey CM. Cardiomyopathy of Friedreich's Ataxia: Use of Mouse Models to Understand Human Disease and Guide Therapeutic Development. Pediatr Cardiol (2011) 32:366–378. PMID: 21360265.

Rayapureddi, Jayanagendra. Tomamichel, Wendy; Walton, Sonia; Payne, Ronald. TAT-fusion protein transduction into isolated mitochondria is accelerated by sodium channel inhibitors. Biochemistry 2010, Oct. PMID: 20925426.

Zhu W, Soonpaa MH, Chen H, Shey W, Liechty EA, Caldwell RL, Shou W, Payne