Faculty

Erik Imel, MD, MS

Erik Imel, MD, MS

Assistant Professor of Medicine and Pediatrics

Phone: (317) 944-3889
Address:
705 Riley Drive, Room 5960
Indianapolis, IN 46202

Bio

Specialty

Pediatric Endocrinology,  Adult Endocrinology

Areas of Interest

Dr. Imel's clinical and research interests include pediatric metabolic bone and mineral disorders, especially hypophosphatemic disorders, calcium disorders, and disorders of low bone density.

After completing his medical degree at the University of Cincinnati, Dr. Imel engaged in a combined internal medicine and pediatrics residency program at the University of Rochester.  Then he completed combined training in both pediatric and adult endocrinology, with a special focus on metabolic bone and mineral disorders.  He is engaged at the national level with the American Society for Bone and Mineral Research.  Dr. Imel's clinical and research interests include pediatric metabolic bone and mineral disorders, especially hypophosphatemic disorders, calcium disorders, and disorders of low bone density.  Dr. Imel also sees patients as adolescents and young adults in his adult endocrinology clinic for bone and mineral disorders and also other endocrine disorders such as congenital adrenal hyperplasia, Turner syndrome, hypopituitarism and McCune-Albright syndrome.

Education

1999 MD, University of Cincinnati
2003 Internal Medicine Pediatrics Residency, University of Rochester
2007 Combined Adult and Pediatric Endocrinology Fellowship, Indiana University
2013 Master's of Science in Clinical Research. Indiana University

Honors & Awards

  Alpha Omega Alpha Medical Honor Society
2011 The Endocrine Society’s International Award for Publishing Excellence in The Journal of Clinical Endocrinology & Metabolism
  The Central Society for Clinical and Translational Research

Clinical

Riley Hospital Outpatient Center
MSA3
705 Riley Hospital Drive
Indianapolis, IN  46202
317-948-1449

Medical Diagnostic Center
550 N.University Blvd.
Indianapolis, IN 46202
317-944-8660 


Research & Grants

Dr. Imel conducts clinical  research in treatment of phosphate disorders including X-linked hypophosphatemia, and pediatric metabolic bone disease. He discovered the interaction of iron in Fibroblast Growth Factor 23 metabolism through his work in autosomal dominant hypophosphatemic rickets.  He also is involved in research in the epidemiology of osteoporosis and clinical treatment outcomes in real-world practice through partnership with the Regenstrief Institute.

Current Grants

NIH (NIAMS)  1K23AR057096 FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.  Role: Principal Investigator. 

Merck- Regenstrief Program in Personalized Health Care Research and Innovation.  Osteoporosis Center of Excellence - Project 1.  Suboptimal Outcomes of Bisphosphonate Treatment, Role:  Project Co- Investigator

Merck- Regenstrief Program in Personalized Health Care Research and Innovation.  Osteoporosis Center of Excellence - Project 2.  Renal Impairment in Osteoporosis.  Role : Project Principal Investigator

NIH R01AR042228-17 Clinical and Genetic Analysis of ADHR.  Role: Project Co- Investigator


Representative PublicationsView All Publications

1. Imel EA, Peacock M, Gray AK, Padgett LR, Hui SL, and Econs MJ. Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans. J Clin Endo Metab, 96(11): 3541-3549, 2011. PMCID:PMC3205884. “Selected for The Endocrine Society’s International Award for Publishing Excellence in The Journal of Clinical Endocrinology & Metabolism in 2011. This prestigious award recognizes the 14 best clinical research papers published in JCEM each year.”

2. Carpenter T, Imel E, Ruppe M, Weber T, Klausner M, Woodell M, Kawakami T, Ito T, Zhang X, Humphrey J, Insogna K, and Peacock M. Effect of an Anti-FGF23 Antibody (KRN23) in X-linked Hypophosphatemia. J Clin Invest. In review

3. Carpenter TO, Imel EA, Holm IA, Jan de Beur SM, and Insogna KL. A Clinician’s Guide to X-linked Hypophosphatemia. J Bone Min Res. 26 (7):1381-1388, 2011. PMCID: PMC3157040

4. Imel EA, DiMeglio LA, Hui, SL, Carpenter TO, Econs MJ. Treatment of XLH with Calcitriol and Phosphate Increases Circulating FGF23 Concentrations. J Clin Endo Metab. 95: 1846–1850, 2010. PMCID: PMC2853995

5. Imel EA, Hui SL, and Econs MJ. FGF23 Concentrations are Variable in Autosomal Dominant Hypophosphatemic Rickets. J Bone Miner Res 22(4):520-526, 2007.

6. Ichikawa S, Imel EA, Kreiter ML, Yu X, Mackenzie DS, Sorenson AH, Goetz R, Mohammadi M, White KE, and Econs MJ. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest. 117(9):2684-2691, 2007. PMCID: PMC1940239

7. Ichikawa S, Traxler EA, Estwick SA, Curry LR, Johnson ML, Sorenson AH, Imel EA, Econs MJ. Mutational Survey of the PHEX Gene in Patients with X-linked Hypophosphatemic Rickets. Bone. 43: 663-666, 2008. PMCID: PMC2579265.