Research

Members of the Division of Pediatric Endocrinology and Diabetology actively participate in numerous clinical and basic research studies, and division members successfully compete for both governmental and non-governmental research funding. The Division participates in several national diabetes research consortiums, including Type 1 Diabetes TrialNet, DirecNet, the Type 1 Diabetes Exchange, and the Immune Tolerance Network.

Current clinical research interests include:

  • Treatment of central precocious puberty
  • Long term outcomes of central precocious puberty
  • Osteogenesis imperfecta
  • Bone disease in children with cystic fibrosis
  • Hypophosphatasia
  • Congenital hypothyroidism
  • Insulin pump usage in children with type 1 diabetes
  • Endothelial progenitor cells in type 1 diabetes
  • Continuous glucose monitoring in type 1 diabetes
  • Immunomodulatory therapies to prevent or modify type 1 diabetes
  • Quality of life in type 1 diabetes
  • Long-term outcomes of growth hormone treatment
  • New agents for treatment of growth hormone deficiency
  • Growth in children with ADHD
  • Treatment of type 2 diabetes
  • Relationship of sleep apnea to insulin resistance and obesity

The Division of Pediatric Endocrinology and Diabetology also includes the Wells Center for Diabetes Research. The goal of the Center for Diabetes Research is to promote the training of scientists whose research will develop new understandings of the basis of diabetes and its complications, and to cultivate basic science research that can speed the discovery of more effective therapies. The Pediatric Diabetes Research Team is committed to understanding the biology and molecular mechanisms that lead to the development of both type 1 and type 2 diabetes in children. Our research team currently has 4 nationally recognized NIH-funded principal investigators whose research focuses on the development, function, and survival of insulin-producing pancreatic islets. These investigators are supported by an outstanding team of researchers at multiple levels, including research faculty, postdoctoral fellows, graduate students, and undergraduates. Our research space is in the state-of-the-art Van Nuys Medical Science Building.

Current areas of laboratory-based research include:

  • Basic diabetes research
  • Pancreatic islets
  • Islet transplantation
  • Pathophysiology of diabetes
  • Molecular pathways
  • Insulin-producing cells
  • Stem cell therapies
  • Targeted therapies