Faculty

Jodi Skiles, MD, MS

Jodi Skiles, MD, MS

Assistant Professor of Pediatrics

Phone: 317-944-8784
Email: jskiles@iupui.edu
Address:
705 Riley Hospital Drive, ROC 4340
Indianapolis, IN 46202

Bio

Specialty

Pediatric Hematology Oncology
Pediatric Stem Cell Transplant

Areas of Interest

Biomarkers of Vincristine Toxicity in Kenyan Children with Cancer, High Risk Leukemia and genetic predictors of response to therapy, Adolescents and Young Adults with cancer.

Bio

I am a homegrown Hoosier.  Born and raised in Frankfort, Indiana, I chose to stay close to home for all of my education and training.  I recently completed my Pediatric Hematology/Oncology fellowship training at Indiana University and subsequently hired on as faculty in the Department of Pediatrics in July 2012, due in large part to the excellent and collegial atmosphere at Riley Hospital for Children.  My position includes 80% protected time for research and 20% clinical time on Pediatric Stem Cell Transplant.  Over the last several years, I have spent 50% of my time in Kenya overseeing the Pediatric Oncology program and conducting translational research as part of the robust IU-Kenya Partnership.  As my husband and I start a family, the amount of time I spend in Kenya will be decreasing, but we plan to remain firmly invested in the continued success of the program.  Socially, I am an avid Colts fan, an outdoor enthusiast, and a competitive game player (especially when it comes to Euchre).

Education

2001 BS Indiana University
2005 MD Indiana University School of Medicine
2013 MS Indiana University Purdue University of Indianapolis

Honors & Awards

  • 2005: Indiana University School of Medicine Dean’s Award – Medical Student of the Year
  • 2005: Riley Hospital for Children Red Shoes Award, Indiana University School of Medicine
  • 2009: Internal Medicine/Pediatrics Chief Resident, Indiana University School of Medicine
  • 2009: Outstanding Internal Medicine/Pediatrics Resident of the year, Indiana University School of Medicine
  • 2011: St. Baldrick’s Foundation Scholar, Indiana University School of Medicine
  • 2011: Indiana Institute of Personalized Medicine Brater Scholar, Indiana University School of Medicine
  • 2012: Walther Cancer Foundation Scholar, Indiana University School of Medicine
  • 2012: 1st place poster in the category of Outstanding Translational Science at the IU Simon Cancer Center Annual Research Day
  • 2013: K12 Child Health Research Career Development Award Recipient

Clinical

Riley Outpatient Center
705 Riley Hospital Drive
Indianapolis, IN 46202
317-944-2143 phone
317-944-3107 fax


Research & Grants

My specific area of interest is the pharmacogenetics of anticancer drugs in children.  This involves the investigation of tumor response in children receiving specific chemotherapeutic agents and the sensitivity of these individuals to the toxic side effects of the drugs.  My goal is to study the clinical relevance of and the relationships between genotype and phenotype of important drug metabolizing enzymes, drug transporters, and drug receptors expressed in germline DNA.  Throughout my research experiences thus far, I have primarily focused on conducting a clinical pharmacology research project at Moi University Teaching and Referral Hospital in Eldoret, Kenya as part of the robust IU-Kenya partnership.  This work will hopefully allow us to optimize vincristine use in pediatric patients in Kenya with the potential for future expansion (with collaboration through my mentors at IU) to children around the world.   Clinically, in addition to my service time for Pediatric Stem Cell Transplant, I would really like to utilize my unique combined internal medicine/pediatrics training to develop an Adolescent and Young Adult Oncology Program at IU.  There are many young adults diagnosed with cancer each year that are (by default) referred to and treated by adult medical oncologists despite the fact that it has been well-established that this population experiences better survival when treated on pediatric treatment protocols.   My goal over the next 3-5 years is to develop both a treatment program and a research platform for AYA cancer patients, specifically regarding high-risk leukemias and pharmacogenetic biomarkers of response to treatment.

1K12HD068371-01A1 - K12 Child Health Research Career Development Award
Funding Agency: NIH
Role: Principal Investigator

HHSN261200800001E – NCI Center for Global Health
Funding Agency: NCI
Role: Principal Investigator

Indiana University Simon Cancer Center Strategic Research in Oncology Award
Funding Agency: Indiana University Melvin and Bren Simon Cancer Center
Role: Principal Investigator

Alex’s Lemonade Stand Foundation Grant
Funding Agency: Alex's Lemonade Stand Foundation
Role: Co-investigator

1U54HD071598-01 – Indiana University Center for Pediatric Pharmacology
Funding Agency: NICHD
Role: Co-investigator


Publications

Bell, C., Skiles J., Champion, V., et al. End of life experiences in adolescents dying with cancer. Supportive Care in Cancer: Volume 18, Issue 7 (2010), Page 827-835. DOI: 10.1007/ s00520-009-0716-1

Skiles, JL, Imel, E., Christenson J., Bell, J. , Hulbert. Fluorosis because of prolonged voriconazole therapy in a teenager with Acute Myelogenous Leukemia. Journal of Clinical Oncology, Vol 29, no. 32 (2011): 779-782. DOI 10.1200/JCO.2011.35.9604

Marsh, Allen, McClain, Weinstein, Washki, Skiles, et al. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. Pediatr Blood Cancer 2012; DOI 10.1002/pbc. Epub ahead of print.

Strother RM, Asirwa FC, Busakhala NB, Skiles JL, et al. AMPATH-Oncology: A model for comprehensive cancer care in sub-Saharan Africa. Journal of Cancer Policy 2013 (ePub ahead of print, http://dx.doi.org/10.1016.j.jcpo.2013.06.002)

Skiles J*, Moormann A*, Koros E, et al. Mentoring future Kenyan Oncology Researchers. Infectious Agents and Cancer 2013, 8:40. http://www.infectagentscancer.com/content/8/1/40

Mostert, S, Njuguna F, Skiles, J, Kaspers, G, et al. Influence of Health-Insurance Status and Hospital Retention Policies on Childhood Cancer Treatment in Kenya. Pediatric Blood & Cancer 2013. ePub ahead of print: DOI: 10.1002/pbc.

Mostert S, Skiles J, Kaspers G. Two overlooked contributors to abandonment of childhood cancer treatment in Kenya: parents’ social network and experiences with hospital retention policy. Accepted to Psycho-Oncology 2013.

Jayachandran D, Ramkrishna U, Skiles J , Renbarger J, Ramkrishna D. Revitalizing Personalized medicine: Respecting Biomolecular Complexities beyond gene expression. CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e110; doi:10.1038/psp.2014.6

Njuguna F, Mostert S, Skiles J, Kaspers G, et al. Abandonment of Childhood Cancer Treatment in Kenya: an Analysis of Causes and Consequences. Arch Dis Child 2014; 0:1-6. doi:10.1136/archdischild-2013-305052.