Kamnesh R. Pradhan, MBBS, MS
Clinical Assistant Professor of Pediatrics
705 Riley Hospital Drive, ROC 4340
Indianapolis, IN 46202
Pediatric Hematology Oncology
Areas of Interest
Biomarkers of pathological angiogenesis in cancer, cancer survivors, and sickle cell anemia, health promotion to enhance vascular health among cancer survivors.
My clinical interests are in pediatric Brain tumors and cancer survivors. My research interests are in early phase anti-angiogenic agents in combination with standard chemotherapy as well as patient-physician communication and health promotion behavior among cancer survivors.
|1988-1994||Medical School, King Edward Memorial Hospital and Seth. G.S. Medical College|
|1997-2000||Residency, University of Illinois at Chicago|
|2000-2004||Fellowship, Indiana University|
Riley Outpatient Center
705 Riley Hospital Drive
Indianapolis, IN 46202
Research & Grants
I am currently involved in studying biomarkers of abnormal angiogenesis among pediatric solid tumor patients. Our goal is to discover predictive biomarkers to anti-angiogenic agents. I am also involved with conducting Phase-1 studies through the Children’s Oncology Phase-1 consortium for novel anti-angiogenic agents. In addition, I have also had training in Behavior Oncology with the goals of health promotion particularly for physical activity behavior among cancer survivors to promote vascular health and fitness using a bio-behavioral theoretical framework. I am studying the role of physical activity on angiogenic biomarkers in cancer survivors. Lastly, I am looking at the differences among angiogenic biomarkers in subjects with sickle cell anemia.
I have had grant funding from Indiana University internal-funding, CTSI and NCI. I am applying for external grant funding through NIH.
Active: R25CA117865 (NIH-NCI) Post-doctoral training grant.
Completed: VFR-342. (Indiana University Health Values grant.) PI CTSI (NIH/NCRR) TR000006. PI
Zaky W, Dhall G, Ji L, Haley K, Allen J, Atlas M, Bertolone S, Cornelius A, Gardner S, Patel R, Pradhan K, Shen V, Thompson S, Torkildson J, Sposto R, Finlay JL. Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid/rhabdoid tumors: the Head Start III experience. Pediatr Blood Cancer. 2014 Jan;61(1):95-101. doi: 10.1002/pbc.24648. Epub 2013 Aug 11. PubMed PMID: 23934933
Mund JA, Shannon H, Sinn AL, Cai S, Wang H, Pradhan KR, Pollok KE, Case J. Human proangiogenic circulating hematopoietic stem and progenitor cells promote tumor growth in an orthotopic melanoma xenograft model. Angiogenesis. 2013 Oct;16(4):953-62. doi: 10.1007/s10456-013-9368-3. Epub 2013 Jul 23. PubMed PMID: 23877751
Quigg TC, Mahajerin A, Sullivan PD, Pradhan K, Bauer NS. Ages and Stages Questionnaires-3 developmental screening of infants and young children with cancer. J Pediatr Oncol Nurs. 2013 Sep-Oct;30(5):235-41. doi: 10.1177/1043454213493510. Epub 2013 Jul 18. PubMed PMID: 23867965
Robertson KA, Nalepa G, Yang FC, Bowers DC, Ho CY, Hutchins GD, Croop JM, Vik TA, Denne SC, Parada LF, Hingtgen CM, Walsh LE, Yu M, Pradhan KR, Edwards-Brown MK, Cohen MD, Fletcher JW, Travers JB, Staser KW, Lee MW, Sherman MR, Davis CJ, Miller LC, Ingram DA, Clapp DW. Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. Lancet Oncol. 2012 Dec;13(12):1218-24. doi: 10.1016/S1470-2045(12)70414-X. Epub 2012 Oct 23. PubMed PMID: 23099009
Viswanathan V, Pradhan KR, Eugster EA. Pituitary hormone dysfunction after proton beam radiation therapy in children with brain tumors. Endocr Pract. 2011 Nov-Dec;17(6):891-6. doi: 10.4158/EP10391.OR. PubMed PMID: 21613054
Pradhan KR, Mund JA, Johnson C, Vik TA, Ingram DA, Case J. Polychromatic flow cytometry identifies novel subsets of circulating cells with angiogenic potential in pediatric solid tumors. Cytometry B Clin Cytom. 2011 Sep;80(5):335-8. doi: 10.1002/cyto.b.20602. Epub 2011 May 12. PubMed PMID: 21567939
Abla O, Weitzman S, Blay JY, O'Neill BP, Abrey LE, Neuwelt E, Doolittle ND, Baehring J, Pradhan K, Martin SE, Guerrera M, Shah S, Ghesquieres H, Silver M, Betensky RA, Batchelor T. Primary CNS lymphoma in children and adolescents: a descriptive analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG). Clin Cancer Res. 2011 Jan 15;17(2):346-52. doi: 10.1158/1078-0432.CCR-10-1161. Epub 2011 Jan 11. PubMed PMID: 21224370
Bell CJ, Skiles J, Pradhan K, Champion VL. End-of-life experiences in adolescents dying with cancer. Support Care Cancer. 2010 Jul;18(7):827-35. doi: 10.1007/s00520-009-0716-1. Epub 2009 Aug 29. PubMed PMID: 19727847
Pradhan KR, Johnson CS, Vik TA, Sender LS, Kreissman SG. A novel intensive induction therapy for high-risk neuroblastoma utilizing sequential peripheral blood stem cell collection and infusion as hematopoietic support. Pediatr Blood Cancer. 2006 Jun;46(7):793-802. PubMed PMID: 16206215
Douglas-Akinwande AC, Mourad AA, Pradhan K, Hattab EM. Primary intracranial germinoma presenting as a central skull base lesion. AJNR Am J Neuroradiol. 2006 Feb;27(2):270-3. PubMed PMID: 16484390