Center for Primary Ciliary Dyskinesia (PCD)
In February 2013, Riley Hospital for Children and the Section of Pediatric Pulmonology, Allergy and Sleep Medicine opened a center of excellence for individuals with Primary Ciliary Dyskinesia (PCD). Riley Hospital for Children is one of the eight centers that serves as a site for the Genetics Disorders of Mucociliary Clearance Research Consortium; as part of this research network, we serve as a diagnostic center for PCD. PCD, a rare disease of the airway, is difficult to diagnose and is often misdiagnosed. Patients with this autosomal recessive disease have abnormal cilia lining their airway, sinuses and ears. Patients may experience neonatal distress, chronic "wet" cough, chronic nasal congestion, and frequent infections of the lungs, ears, throat and sinuses. Chronic respiratory infections may result in irreversible lung changes including bronchiectasis. Approximately 50% of PCD patients also have situs inversus. It is estimated that 400,000 individuals worldwide suffer from PCD, many undiagnosed.