Kathleen M. O'Neil, MD

Kathleen M. O'Neil, MD

Professor of Pediatrics

Phone: 317-274-2172
Email: kmoneil@iu.edu
Division of Pediatric Rheumatology
Riley Hospital for Children, RR307
699 Riley Hospital Drive
Indianapolis, IN 46202



Pediatric Rheumatology

Areas of Interest

Dr. O'Neil specializes in diagnosis and treatment of rheumatic diseases of childhood, including systemic lupus erythematosus, juvenile idiopathic arthritis, juvenile inflammatory myositis, localized and systemic scleroderma, mixed connective tissue disease, vasculitis and autoinflammatory disorders of systemic inflammation.


Dr. O'Neil is the Director of Pediatric Rheumatology, and the Program Director of the Pediatric Rheumatology Fellowship at IUPUI and at Riley Hospital for Children at IU Health.  She joined the faculty at the School of Medicine in 2012 from the University of Oklahoma School of Medicine.  She grew up in Maine, and was educated in Boston, New Haven, CT and Baltimore.  Her clinical interests include all pediatric rheumatic conditions, especially severe multisystem inflammatory disorders.  She coordinates a multi-center collaborative research project studying the effects of hormone changes during puberty on inflammatory disease activity and autoimmunity in children with systemic lupus erythematosus.  Her research strives to understand why autoimmune diseases are more common in females, and why many begin or worsen around the time of puberty.  She is active in multi-center clinical trials of novel medications in childhood inflammatory diseases and is a leader in national and international research organizations.


1974 BA, Wellesley College
1978 M.D., Tufts University School of Medicine
1979-1982 Resident in Pediatrics, Yale-New Haven Hospital
1982-1986 Fellowship in Pediatric Allergy, Immunology and Rheumatology, the Johns Hopkins Hospital

Honors & Awards


  • Faculty Teaching Award – Children’s Hospital of Buffalo Pediatric Residency Program, May 20, 2003
  • Faculty Teaching Award - University of Oklahoma Department of Pediatrics Residency Programm, June 15, 2009
  • Mentor Award, Resident Research Day - University of Oklahoma Health Sciences Center Department of Pediatrics, June 15, 2012


  • National Research Service Award - National Institutes of Health, 5 F32 AI 06972 1984-86
  • Stetler Foundation Research Award - Johns Hopkins University School of Medicine 1986
  • Abbott Medical Student Research Preceptorship - American College of Rheumatology/Research Education Foundation 2009


  • CARRA Steering Committee Representative for Small Academic Rheumatology Centers Elected by Peers 2001-2004
  • Visiting Professor in Pediatric Rheumatology - American Academy of Pediatrics 2002-2003, 2004-2005
  • Executive Committee - American College of Rheumatology Pediatrics Section 2006-2009
  • Amgen Visiting Professor in Pediatric Rheumatology - American College of Rheumatology/Research Education Foundation 2005-2006, 2009-2010, 2010-2011


  • Honors Program, Department of French - Wellesley College 1973-74
  • Alpha Omega Alpha Medical Honor Society 1978
  • Janet M. Glasgow Achievement Award - American Medical Women's Association 1978
  • Career Re-Entry Award - American College of Rheumatology Research and Education Fund 2006-2008
  • Oklahoma's Top Doctors 2004-2012
  • Oklahoma's Best Doctors - Oklahoma Magazine 2005-2012
  • Who's Who in American Medicine 1997-present
  • America's Best Doctors 1998-present
  • Cambridge Who's Who among Executives and Professionals in the field of Research, Medicine and Healthcare 2010-present
  • Cambridge Who's Who among Executives, Professionals and Entrepreneurs 2010-present


Riley Hospital for Children at IU Health
Riley Outpatient Center (ROC), MSA3
705 Riley Hospital Drive, 3rd floor
Indianapolis, IN 46202

IU North Medical Center
11725 N Illinois Street, Suite 450
Carmel, IN 46032


Research & Grants

Dr. O'Neil participates in several multi-center clinical trials of drugs to treat children with arthritis and other rheumatic diseases, in clinical registries and repositories that aim to help understand the diseases themselves and how they work, and in basic and translational studies that investigate the science of how diseases happen and search for biomarkers of disease activity or improvement.  Her major research effort is coordinating a multicenter longitudinal observational study of children with early onset systemic lupus erythematosus as they near and progress through puberty to understand the effects of hormones on lupus, and to understand the female sex predilection of lupus and related autoimmune diseases.  This study gathers data and samples of blood and urine from children every 3 months from late pre-puberty through completion of sexual maturation to identify hormones whose production and activity leads to increases in disease activity, and a more autoimmune phenotype.  In addition, she collaborates with fellow pediatric rheumatologists and researchers in CARRA, the Childhood Arthritis and Rheumatology Research Alliance, to collectively study uncommon or rare rheumatic diseases of childhood.  Her collaborative work has helped advance the understanding and care of children with lupus, juvenile idiopathic arthritis, systemic vasculitis of childhood, localized scleroderma, juvenile dermatomyositis, and very rare genetic disorders of the control of inflammation, the autoinflammatory diseases.

Current Grants

Gene Expression in Pediatric Arthritis, NIH and NIAMS, Site PI, 2% effort per subject 2011-2015

Pubertal Changes in SLE, IU Department of Pediatrics, PI, 25% effort 2012-2015

CARRA Registry, Arthritis Foundation, Site PI, 2% effort per subject 2012-2015

Representative Publications

Cabral DA, Uribe A, Benseler S., O’Neil KM, Hashkes PA, Higgins P, Zeft AS, Lovell DJ, Kingsbury DJ, Stevens A, McCurdy D, Chira P, Abramson L, Arkachaisri T, Campillo S, Eberhard A, Hersch AO, Huber AM, Kim S, Klein-Gitelman M, Levy DM, Li SC, Mason T, Morgan DeWitt E, Muscal E, Nassi L, Reiff A, Schikler K, Singer NG, Wahezi D, Woodward A, for the ARChiVe investigators Network. Classification, presentation and initial treatment of Wegener’s granulomatosis in childhood: An ARChiVe project. Arthritis Rheum. 2009 Nov; 60(11):3413-24. PMID 19877069

Arkachaisri T, Vilaiyuk S, Li S, O’Neil KM, Pope E, Higgins GC, Punaro M, Rabinovich EC, Rosenkranz M, Kietz DA, Rosen P, Spalding SJ, Hennon TR, Torok KS, Cassidy E, Medsger TA, Jr. for the Localized Scleroderma Clinical and Ultrasound Study Group (LOCUS). The localized scleroderma skin severity index (LoSSI) and physician global assessment of disease activity: A work-in-progress toward the development of localized scleroderma outcome measures. J. Rheumatol. 2009 Dec; 36(12):2819-29. PMID 19833758

Li SC, Feldman BM, Higgins GC, Haines KA, Punaro MG, O’Neil KM. Treatment of pediatric localized scleroderma: results of a survey of North American pediatric rheumatologists. J. Rheumatol. 2010 Jan; 37(1):175-81. PMID 19918041

Ruperto N, Ozen S, Pistorio A, Dolezalova P, Brogan P, Cabral DM, Cuttica R, Khubchandani R, Lovell D, O'Neil KM, Quartier P, Ravelli A, Iusan SM, Filocamo G, Magalhaes CS, Unsal E, Oliveira S, Bracaglia C, Bagga A, Stanevicha V, Magni Manzoni S, Pratsidou P, Lepore L, Espada G, Kone Paut I, Zulian F, Barone P, Bircan Z, del Rocio Maldonado M, Russo R, Vilca I, Tullus K, Cimaz R, Horneff G, Anton J, Garay S, Nielsen S, Barbano G, Martini A, for the Paediatric Rheumatology International Trials Organisation (PRINTO) EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterization. Ann Rheum Dis 2010 May; 69(5):790-7. PMID 20388738

O’Neil KM*, Varma C, Farooq O, Memon A. Glucocorticoid responsive hypertension in Henoch-Schonlein purpura. Clinical Ped 2010 Jul; 49(7):702-6. PMID 20164069

Boyer EM, Turman M, O’Neil KM.* Response to Anakinra in life-threatening Henoch Schonlein Purpura: Case Report. Pediatric Rheumatol 2011 Aug 11; 9(1):21. PMID 21834965

Mina R. Klein-Gitelman MS. Ravelli A. Beresford MW. Avcin T. Espada G. Eberhard BA. Schanberg LE. O'Neil KM. Silva CA. Higgins GC. Onel K. Singer NG. von Scheven E. Imundo LF. Nelson S. Giannini EH. Brunner HI. Inactive disease and remission in childhood-onset systemic lupus erythematosus. Arthritis Care Res 2012 May; 64(5):683-93. PMID 22238253

Morishita K. Li SC. Muscal E. Spalding S. Guzman J. Uribe A. Abramson L. Baszis K. Benseler S. Bowyer S. Campillo S. Chira P. Hersh AO. Higgins G. Eberhard A. Ede K. Imundo L. Jung L. Kim S. Kingsbury DJ. Klein-Gitelman M. Lawson EF. Lovell DJ. Mason T. McCurdy D. Nanda K. Nassi L. O'Neil KM. Rabinovich E. Ramsey SE. Reiff A. Rosenkranz M. Schikler K. Stevens A. Wahezi D. Cabral DA. ARChiVe Investigators Network. Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe). J. Rheumatology 2012 May; 39(5):1088-94. PMID 22337238

Wallace CA. Giannini EH. Spalding SJ. Hashkes PJ. O'Neil KM. Zeft AS. Szer IS. Ringold S. Brunner HI. Schanberg LE. Sundel RP. Milojevic D. Punaro MG. Chira P. Gottlieb BS. Higgins GC. Ilowite NT. Kimura Y. Hamilton S. Johnson A. Huang B. Lovell DJ. Childhood Arthritis and Rheumatology Research Alliance. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum 2012 June; 64(6):2012-21. PMID 22183975

Ilowite NT, Sandborg CI, Feldman BM, Grom A, Schanberg LE, Giannini EH, Wallace CA, Schneider R, Kenney K, Gottlieb B, Hashkes PJ, Imundo L, Kimura Y, Lang B, Miller M, Milojevic D, O’Neil, KM, Punaro M, Ruth N, Singer NG, Vehe RK, Verbsky J, Woodward A, Zemel L. Algorithm development for corticosteroid management in systemic juvenile idiopathic arthritis using consensus methodlogy. Pediatric Rheumatol 2012 Aug 29; 10(1):31. PMID 22931206

Li SC. Torok KS. Pope E. Dedeoglu F. Hong S. Jacobe HT. Rabinovich CE. Laxer RM. Higgins GC. Ferguson PJ. Lasky A. Baszis K. Becker M. Campillo S. Cartwright V. Cidon M. Inman CJ. Jerath R. O'Neil KM. Vora S. Zeft A. Wallace CA. Ilowite NT. Fuhlbrigge RC. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res. 2012 Aug; 64(8):1175-85. PMID 22505322

Uribe AG. Huber AM. Kim S. O'Neil KM. Wahezi DM. Abramson L. Baszis K. Benseler SM. Bowyer SL. Campillo S. Chira P. Hersh AO. Higgins GC. Eberhard A. Ede K. Imundo LF. Jung L. Kingsbury DJ. Klein-Gitelman M. Lawson EF. Li SC. Lovell DJ. Mason T. McCurdy D. Muscal E. Nassi L. Rabinovich E. Reiff A. Rosenkranz M. Schikler KN. Singer NG. Spalding S. Stevens AM. Cabral DA. ARegistry for Children with Vasculitis e-entry (ARChiVe) Network. Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis. J Rheumatology 2012 Aug; 39(8):1687-97. PMID 22589257

Morishita K. Guzman J. Chira P. Muscal E. Zeft A. Klein-Gitelman M. Uribe AG. Abramson L. Benseler SM. Eberhard A. Ede K. Hashkes PJ. Hersh AO. Higgins G. Imundo LF. Jung L. Kim S. Kingsbury DJ. Lawson EF. Lee T. Li SC. Lovell DJ. Mason T. McCurdy D. O'Neil KM. Punaro M. Ramsey SE. Reiff A. Rosenkranz M. Schikler KN. Scuccimarri R. Singer NG. Stevens AM. van Mater H. Wahezi DM. White AJ. Cabral DA. ARChiVe Investigators Network. Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions. J Rheumatology. 2012 Oct; 39(10):2012-20. PMID 22859342

Bernatsky S, Clarke AE, Labreque J, von Scheven E, Schanberg LE, Silverman ED, Brunner HI, Haines KA, Cron RQ, O’Neil KM, Oen K, Rosenberg AM, Duffy CM, Joseph L, Lee JL, Kale M, Turnbull EM, Ramsey-Goldman R. Cancer risk in childhood-onset systemic lupus. Arthritis Res & Therapy. 2013; 15(6):R198. PMID: 24267155

Wyrick S, Hester C, Sparkman A, O’Neil KM, DuPuis G, Anderson M, Cordell J, Bogie A. What Role Does Body Mass Index Play in Hospital Admission Rates From the Pediatric Emergency Department. Pediatric Emergency Care. 2013 Sep; 29(9):974-8. PMID: 23974715

Dolezalova P, Price-Kuehne FE, Ozen S, Benseler SM, Cabral DA, Anton J, Brunner J, Cimaz R, O’Neil KM, Wallace CA, Wilinson N, Eleftheriou D, Demirkaya E, Bohm M, Krol P, Luqmani RA, Brogan PA. Disease activity assessment in childhood vasculitis: development and preliminary validation of the Paediatric Vasculitis Activity Score (PVAS). Ann Rheum Dis 2013 Oct; 72(10):1628-33. PMID 23100606

Mina R, Klein-Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, Onel K, Tucker L, O'Neil KM, Punaro M, Levy DM, Haines K, Martini A, Ruperto N, Lovell D, Brunner HI. Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus. Ann Rheum Dis. 2014 Feb; 73(2):401-6. PMID: 23345596

Wallace, CA; Giannini, EH; Spalding, SJ; Hashkes, PJ; O’Neil, KM; Zeft, AS; Szer, IS; Ringold, S; Brunner, HI; Schanberg, LE; Sundel, RP; Milojevic, DS; Punaro, MG; Chira, P; Gottlieb, BS; Higgins, GC; Ilowite, NT; Kimura, Y; Johnson, A; Huang, B; Lovell, DJ for the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Clinically Inactive Disease in a Cohort of Children with New Onset Polyarticular Juvenile Idiopathic Arthritis Treated with Early Aggressive Therapy: Time to Achievement, Total Duration, and Predictors. Journal of Rheumatology. 2014 Jun; 41(6):1163-70. PMID: 24786928

Ilowite NT, Prather K, Lokhnygina Y, Schanberg LE, Elder M, Milojevic D, Verbsky JW, Spaulding SJ, Kimura Y, Imundo LF, Punaro MG, Sherry DD, Tarvin SE, Zemel LS, Birmingham JD, Gottlieb BS, Miller ML, O’Neil K, Ruth NM, Wallace CA, Singer NG, Sandborg CI. The randomized placebo phase study of rilonacept in the treatment of systemic juvenile idiopathic arthritis. Arthritis Rheum. 2014 Sept; 66(9): 2570–9. PMID 24839206

Wallace CA, Ringold S, Bohnsack J, Spaulding SJ, Brunner HI, Milojevic D, Schanberg LE, Higgins GC, O’Neil KM, Gottlieb BS, Hsu J, Punaro MG, Kimura Y, Hendrickson A. Extension Study of Participants from the Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis. J Rheumatol. 2014 Dec;41(12):2459-65. PMID 25179849